Human umbilical cord mesenchymal stem cells repair islet structure and function in diabetic rats through metabolic reprogramming

doi:10.4252/wjsc.122760

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Oct 26, 2026; 18(10): 122760
Published online Oct 26, 2026. doi: 10.4252/wjsc.122760

Table 1 Detailed information of 30 key differential metabolites

Metabolite ID	Metabolite name	DM vs control		DM + hUC-MSCs vs DM
Metabolite ID	Metabolite name	Log₂FC	Type	Log₂FC	Type
MEDP1339	LPC(18:1/0:0)	-0.327	Down	-0.240	Down
MW0015937	Asclepin	-0.748	Down	-0.621	Down
MW0141637	17-phenyl trinor Prostaglandin F2 cyclopropyl amide	-1.688	Down	-0.950	Down
MW0055257	N-Cyclopropyl-trans-2-cis-6-nonadienamide	-1.118	Down	1.541	Up
MW0006200	MS-PPOH	-0.870	Down	-0.697	Down
MEDTN02450	N-(Cyclopropylmethyl)-7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpent-1-EN-1-YL)cyclopentyl]hept-5-enamide	-0.916	Down	-2.084	Down
MW0152407	Leu-Leu-Trp	-1.244	Down	1.942	Up
MW0144473	Ala-Arg-His	-0.681	Down	1.264	Up
MW0123754	Doramapimod	-2.032	Down	2.050	Up
MW0054549	LysoPC(22:2(13Z,16Z))	-0.553	Down	0.715	Up
MW0053755	2-[[4-(3,12-dihydroxy-10,13-dimethyl 2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1-oxopentyl]amino]acetic acid	-1.625	Down	1.519	Up
MW0014969	6-{[1-(2-{[2-(3,4-dimethoxyphenyl)ethyl]-C-hydroxycarbonimidoyl}eth-1-en-1-yl)-3-methoxy-4-oxocyclohexa-2,5-dien-1-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid	-0.962	Down	-0.553	Down
MW0128176	(4-{2-[(1R,16Z,24E,26E,28Z)-1,18-dihydroxy-23-(hydroxymethyl)-19,30-dimethoxy-15,17,21,29,35-pentamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0,]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl}-2-methoxycyclohexyl)oxidanesulfonic acid	-4.293	Down	-0.637	Down
MEDN0785	LTB4	-1.503	Down	-0.862	Down
MW0113931	Amygdalin	-1.227	Down	1.407	Up
MW0106148	Chorismic acid	-3.216	Down	2.256	Up
MW0055456	O-Decanoyl-L-carnitine	-1.405	Down	-0.717	Down
MW0012191	12,13-DiHOME	-1.340	Down	-0.627	Down
MW0154243	N-acetyl-N6,N6,O-tridemethylpuromycin-5’-phosphate	-0.731	Down	-0.548	Down
MW0148399	Diacetyl-10-gingerdiol	-1.228	Down	-1.269	Down
MW0157815	Thr-Thr-Gly-Leu-Ile	-0.496	Down	-0.726	Down
MW0149707	Gln-His-Ser-Ser-Leu	0.989	Up	-1.118	Down
MW0123548	Deoxykhivorin	1.904	Up	-0.992	Down
MEDP1343	LPC(0:0/18:3)	0.483	Up	-1.125	Down
MW0152097	L-a-lysophosphatidylserine	0.919	Up	-1.303	Down
MW0151632	Ile-Tyr-Phe-Glu	0.800	Up	-1.079	Down
MW0155794	Pro-Asn-Gln-Met-Ser	0.931	Up	-0.736	Down
MW0114597	HMBOA-Glc	0.684	Up	0.467	Up
ZINC1629864	Gyrophoric acid	0.562	Up	-0.764	Down
FDATN00900	D-Arabinose	1.707	Up	0.582	Up

Control group, n = 8; diabetes mellitus (DM) group, n = 6; DM + human umbilical cord mesenchymal stem cells group, n = 5. FC: Fold change; DM: Diabetes mellitus; hUC-MSCs: Human umbilical cord mesenchymal stem cells.

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Citation: Xu J, Yang X, Zhang HY, Wang LL, Luo YD, Yang SL, Zhou YJ, Liu Y, Yang XF. Human umbilical cord mesenchymal stem cells repair islet structure and function in diabetic rats through metabolic reprogramming. World J Stem Cells 2026; 18(10): 122760
URL: https://www.wjgnet.com/1948-0210/full/v18/i10/122760.htm
DOI: https://dx.doi.org/10.4252/wjsc.122760

Xu J, Yang X, Zhang HY, Wang LL, Luo YD, Yang SL, Zhou YJ, Liu Y, Yang XF. Human umbilical cord mesenchymal stem cells repair islet structure and function in diabetic rats through metabolic reprogramming. World J Stem Cells 2026; 18(10): 122760 [DOI: 10.4252/wjsc.122760]

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