Therapeutic potential of umbilical cord-derived mesenchymal stem cells in ameliorating ovarian aging: Insights from single-cell analysis

Figure 8 Umbilical cord-derived mesenchymal stem cell transplantation remodels the intercellular communication network in the aged ovary. A: The total number of inferred interactions (left) and the total interaction strength (right) among all cell populations are increased in the umbilical cord-derived mesenchymal stem cell transplantation (A-MSC) group compared to the aged control (A-CON) group; B: Analysis of interactions identifies stromal cells exhibiting the most significant alterations in signaling pathways following A-MSC; C: Chord diagrams of transforming growth factor (TGF)-β signaling pathway network in A-CON group (left) and A-MSC group (right); D: Alterations in ligand-receptor pairs of the TGF-β signaling pathway; E: Alterations in ligand-receptor pairs of the chemokine pathway; F: Alterations in ligand-receptor pairs of the collagen pathways. GC: Granulosa cell; SC: Stromal cell; TC: Theca cell; EndoC: Endothelial cell; EpiC: Epithelial cell; IC: Immune cell; A-CON: Aged control; A-MSC: Umbilical cord-derived mesenchymal stem cell transplantation; TGF: Transforming growth factor.