Extracellular vesicles derived from human amniotic fluid stem cells improve bladder dysfunction in rat model of diabetic atherosclerosis

Figure 4 Histological findings of the common iliac arteries. The intima thickness of the common iliac arteries in the diabetic atherosclerosis group significantly increased compared with the control and diabetes mellitus groups. However, the intima thickness of diabetic atherosclerosis rats treated with human amniotic fluid stem cell-derived extracellular vesicles was significantly reduced at 4 weeks after induction. Bars indicate 400 μm. A: Hematoxylin and eosin staining of the common iliac arteries; B: Common iliac artery wall thickness. ^aP < 0.05 vs normal control, ^bP < 0.05 vs diabetes mellitus, ^cP < 0.05 vs diabetic atherosclerosis. DM: Diabetes mellitus; DMA: Diabetic atherosclerosis; hAFSC-EVs: Human amniotic fluid stem cell-derived extracellular vesicles.