Hypoxia facilitates triple-negative breast cancer stem cells enrichment and stemness maintenance through oxidized ataxia telangiectasia mutated-induced one-carbon metabolism

Figure 3 Hypoxia and oxidized ataxia telangiectasia mutated facilitate metabolic remodeling in triple-negative breast cancer-cancer stem cells. A: Volcano plot showing differentially regulated metabolites (115 upregulated, 129 downregulated) in MDA-MB-231 cancer stem cells under hypoxia compared with normoxia; B: Pathway enrichment analysis of differentially regulated metabolites; C: Kyoto Encyclopedia of Genes and Genomes classification of altered metabolic pathways; D: Volcano plot showing metabolic changes in hypoxic cancer stem cells after Ku60019 treatment; E: Pathway enrichment analysis after Ku60019 treatment; F: Kyoto Encyclopedia of Genes and Genomes classification of altered metabolic pathways after Ku60019 treatment.