Breast cancer stem cell activity driven by ME18D gene expression in the tumor microenvironment

Figure 4 Validation of risk score model and single-cell transcriptomic analysis. A: Risk score distribution showing significant differences between high-risk and low-risk groups (P < 0.001); B: Clinical feature correlation analysis displaying associations between risk scores and various clinicopathological characteristics; C and D: Expression validation of core model genes demonstrating significant differential patterns between risk groups (P < 0.001); E and F: T-SNE visualization of single-cell RNA sequencing data revealing distinct cell subpopulations with different transcriptional characteristics; G: Cell type annotation showing subpopulations with stem cell-like features characterized by high expression of pluripotency and self-renewal genes.