Post-translational modifications in osteogenic differentiation of oral-derived stem cells: Mechanisms and clinical implications

doi:10.4252/wjsc.v17.i9.109662

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 9

This Article

(49)

(0)

(1099)

(2)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Stem Cells

ISSN

1948-0210

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

World J Stem Cells. Sep 26, 2025; 17(9): 109662
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.109662

Table 2 Post-translational modification-mediated crosstalk mechanisms in osteogenic signaling

PTM type	Molecular target	Pathway interaction	Functional consequence	Ref.
Acetylation	β-catenin (Lys49)	Wnt-BMP synergy	Enhanced β-catenin/SMAD1 complex stability	[33,37-39]
Methylation	SMAD4 (Arg37)	BMP-Wnt-PI3K integration	Facilitated β-catenin nuclear translocation	[41-43]
Lactylation	H3K18 histone mark	Metabolic-epigenetic coupling	Chromatin priming at osteogenic loci	[44,46,47]
Phosphorylation	GSK3β (Ser9)	PI3K-Wnt crosstalk	β-catenin stabilization	[35,36]
Ubiquitination	SMAD1 (Lys519)	BMP-TGFβ balance	Regulation of SMAD1/2/3 stoichiometry	[52,53]

PTM: Post-translational modification; GSK3β: Glycogen synthase kinase 3 beta; BMP: Bone morphogenetic protein; PI3K: Phosphatidylinositol 3-kinase; TGF: Transforming growth factor.

Full Size Table

Citation: Shi ZJ, Liu W. Post-translational modifications in osteogenic differentiation of oral-derived stem cells: Mechanisms and clinical implications. World J Stem Cells 2025; 17(9): 109662
URL: https://www.wjgnet.com/1948-0210/full/v17/i9/109662.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i9.109662

Shi ZJ, Liu W. Post-translational modifications in osteogenic differentiation of oral-derived stem cells: Mechanisms and clinical implications. World J Stem Cells 2025; 17(9): 109662 [PMID: 41025108 DOI: 10.4252/wjsc.v17.i9.109662]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.