HOX and MEINOX in cellular plasticity, fibrosis, and cancer

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Sep 26, 2025; 17(9): 109102
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.109102

Table 1 HOX and MEINOX molecules in fibrosis related mechanisms and associated pathways

Mechanism	HOX-MEINOX molecule	Associated pathway(s)	Effect of molecule on pathway	Ref.
Myofibroblast differentiation	HOXA9	Wnt/β-catenin	Inhibition	[79]
	miR-196a/b	TGF-β	Inhibition	[117]
	miR-10a/b	TGF-β	Inhibition	[197]
	HOTTIP	TGF-β	Stimulation	[112]
ECM production	HOTTIP	TGF-β	Inhibition	[110]
	HOXA11	PDGF	Stimulation	[105]
	HOXA11	TGF-β	Stimulation	[106]
	HOXB7	Wnt/β-catenin	Stimulation	[108]
	HOXA9	Wnt/β-catenin	Stimulation	[79]
	HOXA11-AS	TGF-β	Stimulation	[107]
Fibroblast migration	HOXA11	PDGF	Stimulation	[106]
Fibroblast survival	MEIS1	TGF-β	Inhibition	[6]
Fibroblast survival	HOTTIP	TGF-β	Stimulation	[110,112]
Fibroblast activation	miR-10a/b	TGF-β	Stimulation	[114,197]
	HOXA11	TGF-β	Stimulation	[105,107]
	HOTAIR	Notch	Stimulation	[91]

TGF: Transforming growth factor; PDGF: Platelet derived growth factor; ECM: Extracellular matrix.

Citation: Keleş M, Gunel-Ozcan A. HOX and MEINOX in cellular plasticity, fibrosis, and cancer. World J Stem Cells 2025; 17(9): 109102
URL: https://www.wjgnet.com/1948-0210/full/v17/i9/109102.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i9.109102

Keleş M, Gunel-Ozcan A. HOX and MEINOX in cellular plasticity, fibrosis, and cancer. World J Stem Cells 2025; 17(9): 109102 [PMID: 41025109 DOI: 10.4252/wjsc.v17.i9.109102]

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