Stem cell-based cartilage regeneration: Biological strategies, engineering innovations, and clinical translation

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 9

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Stem Cells

ISSN

1948-0210

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Stem Cells. Sep 26, 2025; 17(9): 108523
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.108523

Table 2 Animal models for preclinical cartilage regeneration

Species	Cartilage thickness	Advantages	Limitations
Mouse	20-30 μm	Low cost, genetic models available	Extremely thin cartilage, not load-bearing
Rat	100-150 μm	Inexpensive, widely used, easy handling	Thin cartilage, less similar to humans
Rabbit	200-300 μm	Moderate size, suitable for defect modeling	Rapid healing not reflective of humans
Goat	1000-2000 μm	Load-bearing joints, similar cartilage size	Higher cost, ethical concerns
Pig	900-1300 μm	Joint size, cartilage thickness similar to humans	Expensive, difficult handling
Sheep	700-1200 μm	Weight-bearing joints, suitable for long-term studies	Expensive, anatomical differences

Citation: Cong B, Zhang FH, Zhang HG. Stem cell-based cartilage regeneration: Biological strategies, engineering innovations, and clinical translation. World J Stem Cells 2025; 17(9): 108523
URL: https://www.wjgnet.com/1948-0210/full/v17/i9/108523.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i9.108523

Cong B, Zhang FH, Zhang HG. Stem cell-based cartilage regeneration: Biological strategies, engineering innovations, and clinical translation. World J Stem Cells 2025; 17(9): 108523 [PMID: 41025101 DOI: 10.4252/wjsc.v17.i9.108523]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.