Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration

Figure 5 Exosomes derived from bone marrow mesenchymal stem cells lactate dehydrogenase A promotes chondrocyte stem cells proliferation by upregulating bone morphogenetic protein 7. A: Protein expression levels of lactate dehydrogenase A and bone morphogenetic protein 7 in chondrocyte stem cells (CSPCs) after different treatments; B: Lactate content secreted by CSPCs; C: Cell viability measured by cell counting kit 8; D: Protein levels of type II collagen, SOX9 and aggrecan in CSPCs. ^bP < 0.01 vs control. LDHA: Lactate dehydrogenase A; BMSC-Exo: Exosomes derived from bone marrow mesenchymal stem cell; BMP: Bone morphogenetic protein 7.