Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration

Figure 3 Exosomes derived from bone marrow mesenchymal stem cells promotes the proliferation and differentiation of chondrocyte stem cells. A: Western blotting showed the presence of exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) lactate dehydrogenase A; B: Extracellular lactate content analysis; C: Cell counting kit 8 analysis of the effect of BMSC-Exos on chondrocyte stem cells proliferation; D: Expression of collagen II, SOX9 and aggrecan proteins and genes in chondrocyte stem cells after co-incubation with BMSC-Exos. ^aP < 0.05 vs control, ^bP < 0.01 vs control. LDHA: Lactate dehydrogenase A; BMSC-Exo: Exosomes derived from bone marrow mesenchymal stem cell.