Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration

Figure 2 Exosomes derived from bone marrow mesenchymal stem cells promotes anterior cruciate ligament reconstruction tendon bone healing. A: Lactate dehydrogenase A protein expression in bone tissues of anterior cruciate ligament reconstruction rats; B: Representative micro-computed tomography images of the humeral head in each group at week 8 postoperatively; C: Representative images of hematoxylin and eosin staining in different treatment groups with quantification of histological scores; D: Safranin O-Fast green staining of the tendon-bone interface and quantification of fibrocartilage in the interface region. LDHA: Lactate dehydrogenase A; ACLR: Anterior cruciate ligament reconstruction; Exo: Exosomes; HE: Hematoxylin and eosin; SOFG: Safranin O-Fast green.