Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration

doi:10.4252/wjsc.v17.i9.106282

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Sep 26, 2025; 17(9): 106282
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.106282

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Figure 1 Exosomes derived from bone marrow mesenchymal stem cells highly expresses lactate dehydrogenase A. A and B: Representative transmission electron microscopy images and particle size distribution curves of exosomes derived from bone marrow mesenchymal stem cells; C: Images of chondrocyte stem cells uptake of PKH26-labeled exosomes derived from bone marrow mesenchymal stem cells; D: Protein expression analysis of lactate dehydrogenase A. LDHA: Lactate dehydrogenase A.

Citation: Zhang T, Huang Q, Gan KF. Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration. World J Stem Cells 2025; 17(9): 106282
URL: https://www.wjgnet.com/1948-0210/full/v17/i9/106282.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i9.106282

Zhang T, Huang Q, Gan KF. Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration. World J Stem Cells 2025; 17(9): 106282 [PMID: 41025103 DOI: 10.4252/wjsc.v17.i9.106282]

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