Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration

doi:10.4252/wjsc.v17.i9.106282

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 9

This Article

(51)

(44)

(0)

(1)

(842)

(4)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Stem Cells

ISSN

1948-0210

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Stem Cells. Sep 26, 2025; 17(9): 106282
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.106282

Table 1 Micro-computed tomography quantitative analysis of tendon-bone healing

Group	BMD (g/cm³)	BV/TV (%)	Tb.Th (mm)
PBS control	0.15 ± 0.03	18.7 ± 3.2	0.09 ± 0.02
BMSC-Exos	0.31 ± 0.04^a	35.6 ± 4.5^a	0.15 ± 0.03^a
BMSC-Exos shLDHA	0.16 ± 0.03^b	19.2 ± 2.8^b	0.09 ± 0.01^b

^aP < 0.001 vs phosphate buffered saline control.

^bP < 0.05 vs exosomes derived from bone marrow mesenchymal stem cells.

Data are mean ± SD (n = 12/group). BMD: Bone mineral density; BV/TV: Bone volume fraction; Tb.Th: Trabecular thickness; PBS: Phosphate buffered saline; BMSC-Exos: Exosomes derived from bone marrow mesenchymal stem cell; LDHA: Lactate dehydrogenase A.

Full Size Table

Citation: Zhang T, Huang Q, Gan KF. Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration. World J Stem Cells 2025; 17(9): 106282
URL: https://www.wjgnet.com/1948-0210/full/v17/i9/106282.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i9.106282

Zhang T, Huang Q, Gan KF. Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration. World J Stem Cells 2025; 17(9): 106282 [PMID: 41025103 DOI: 10.4252/wjsc.v17.i9.106282]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.