Stem cell-derived neural organoids as platforms to investigate glioblastoma invasion and migration: A systematic review

Figure 3 Characterization of experimental models used to investigate glioblastoma invasion in neural organoids. The figure presents the main methodological parameters reported in the included studies, including tumor model type (suspension cells or spheroids), cell type and source (including glioblastoma stem cells and established line), fluorescent markers used, stem cell types used for organoid generation (human induced pluripotent stem cells, and human embryonic stem cells) and their sources. It also shows the number of tumor cells used in invasion/migration assays and the age of the organoids at the time of analysis. GSCs: Glioblastoma stem cells; GFP: Green fluorescent protein; EGFP: Enhanced green fluorescent protein; H2B-GFP: Histone-fused construct green fluorescent protein; hiPSCs: Human induced pluripotent stem cells; hESCs: Human embryonic stem cells; NR: Not reported.