Therapeutic potential of mesenchymal stem cells in neurodegenerative diseases

doi:10.4252/wjsc.v17.i8.107717

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 8

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (817)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-6) series.

Item

Count

PDF

HTML

499

Figures (1-2)

Tables (1-6)

Sum=585

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

Sum=141

Publishing Process of This Article

Item

Count

Browse

Download

Sum=74

Aug 26, 2025 (publication date) through Aug 24, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Stem Cells

ISSN

1948-0210

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Stem Cells. Aug 26, 2025; 17(8): 107717
Published online Aug 26, 2025. doi: 10.4252/wjsc.v17.i8.107717

Table 6 Summary of therapeutic efficacy and safety of mesenchymal stem cells and their derivatives in Niemann-Pick disease type C

Animal model	Source	Type	Administration method	Main outcomes	Ref.
NP-C Gsbs^GFP mice	Mice	BM-MSCs	IV	Improve degenerative loss of Purkinje neurons	[194]
BALB/c npc^nih (NPC) mice	Mice	BM-MSCs	Cerebellum injection	Promote neuronal networks with functional synaptic transmission	[195]
BALB/c npc^nih (NPC) mice	Mice	BM-MSCs	Cerebellum injection	Upregulate fusion ability of Purkinje neurons and donor-derived BM-MSCs	[196]
BALB/c npc^nih (NPC) mice	Mice	BM-MSCs	Cerebrum injection	Modulate endogenous NPC NSCs, stimulate NSC proliferation and neuronal differentiation	[199]
BALB/c npc^nih (NPC) mice	Mice	BM-MSCs	Cerebellum injection	Inhibit activation of astrocytes and microglia, reduce inflammation	[197]
BALB/c npc^nih (NPC) mice	Mice	BM-MSCs	Cerebellum injection	Release bioactive neurotrophic factors, modulate sphingolipid metabolism of endogenous NPC Purkinje neurons	[198]
BALB/c npc^nih (NPC) mice	Mice	ADSCs	Cerebellum injection	Rescue Purkinje neurons, restore motor coordination, and alleviate inflammatory responses	[201]
BALB/c npc^nih (NPC) mice	Human	hUC-MSCs	HIPP injection	Stimulate endogenous neurogenesis, diminish intracellular cholesterol accumulation, and safeguard motor functionality	[200]
BALB/c npc^nih (NPC) mice	Human	hUC-MSCs	IN	Reduce cholesterol levels, decrease loss of Purkinje cells in the cerebellum, delay motor dysfunction	[202]
Npc1^KO N2a cells	Human	MenSCs-CM	Coculture	Increase survival rate, significantly alleviate inflammatory responses and apoptosis	[203]

NPC: Nimman-Pick disease type C; BM-MSCs: Bone marrow-derived mesenchymal stem cells; IV: Intravenous injection; NSCs: Neural stem cells; ADSCs: Adipose-derived mesenchymal stem cells; hUC-MSCs: Human umbilical cord-derived mesenchymal stem cells; HIPP: Hippocampus; IN: Intranasal administration; Npc1^KO N2a cells: Npc1 gene knockout neuro-2a cells; MenSC-CM: Menstrual blood-derived endometrial stem cell conditioned medium.

Citation: Cui CX, Shao XN, Li YY, Qiao L, Lin JT, Guan LH. Therapeutic potential of mesenchymal stem cells in neurodegenerative diseases. World J Stem Cells 2025; 17(8): 107717
URL: https://www.wjgnet.com/1948-0210/full/v17/i8/107717.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i8.107717