Roles of intestinal stem cells in inflammatory bowel disease pathogenesis

Figure 1 Intestinal stem cell niche and cell types in crypt-villus structures. A: The intestinal crypt-villus axis and neighboring niche cells; B: Fibroblast growth factor binding protein 1 positive intestinal stem cells regenerate all lineages and leucine-rich repeat-containing G protein-coupled receptor 5 positive cells. Fibroblast growth factor binding protein 1 secreted by upper crypt intestinal stem cells is essential for intestinal epithelial regeneration. Images created with BioRender.com (Supplementary material). ISCs: Intestinal stem cells; Fgfbp1: Fibroblast growth factor binding protein 1; Lgr5: Leucine-rich repeat-containing G protein-coupled receptor 5; CBC: Crypt based columnar cell.