Current perspectives on regenerative potential of mesenchymal stem cells in alleviating cardiac injuries: Molecular pathways and therapeutic enhancement

doi:10.4252/wjsc.v17.i8.107480

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Aug 26, 2025; 17(8): 107480
Published online Aug 26, 2025. doi: 10.4252/wjsc.v17.i8.107480

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Figure 1 Multiplicity of mesenchymal stem cells’ cardio-protective signaling mechanisms. Created in BioRender (Supplementary material). MSC: Mesenchymal stem cell; IL: Interleukin; TGF: Transforming growth factor; IFN: Interferon; HGF: Hepatocyte growth factor; PGE2: Prostaglandin E2; VEGF: Vascular endothelial growth factor; PI3K: Phosphatidylinositol-3-kinase; AKT: Protein kinase B; MMP: Matrix metalloprotease; SDF: Stromal-derived factor; IGF: Insulin-like growth factor.

Citation: ShamsEldeen AM, Hosny SA, Maghib K, Ashour H. Current perspectives on regenerative potential of mesenchymal stem cells in alleviating cardiac injuries: Molecular pathways and therapeutic enhancement. World J Stem Cells 2025; 17(8): 107480
URL: https://www.wjgnet.com/1948-0210/full/v17/i8/107480.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i8.107480