Therapeutic potential of stem cell-derived exosomes in hair regeneration: A systematic review

Table 5 On-going clinical trials registered on ClinicalTrials.gov, Clinical Trials Registry - India, and Chinese Clinical Trial Register till February 2025, evaluating the safety and/or efficacy of exosomes for hair regeneration

Study identifier	Title of the study	Source of exosomes	Study phase; estimated enrollment (n)	Primary outcome measure(s)	Recruitment status	Study location(s)
NCT06571799	Study evaluating the efficacy and safety of BENEV exosome regenerative complex+ for self-perceived thinning hair	Adipose tissue stem cell-derived exosomes	Not applicable; n = 30	Change in terminal hair counts, change in vellus hair counts, change in total hair counts (time frame: Baseline to day 120 or end of study visit)	Completed	United States
NCT05658094	Exosome effect on prevention of hair loss	Human amniotic mesenchymal stem cells-derived exosomes	Not applicable; n = 20	Change in mean total hair density (hair/cm2) (time frame: 0, 3 and 6 months), visual assessment before and after (time frame: 6 months)	Unknown	Iran
NCT06482541	Efficacy and safety of AGE ZERO™ exosomes to treat men and women with androgenetic alopecia	Wharton’s jelly mesenchymal stem cell-derived exosome	Phase I; n = 100	Hair count, hair thickness, hair color (time frame: Evaluated on monthly visits for a year)	Not yet recruiting	United States
NCT06539273	Exosome treatment in androgenetic alopecia	Foreskin-derived mesenchymal stromal cells derived exosome	Phase III; n = 30	Hair density (time frame: 4 and 12 weeks)	Completed	Turkey
NCT06697080	Umbilical cord-derived mesenchymal stem cell exosomes on hair growth in patients with androgenetic alopecia	Umbilical cord-derived mesenchymal stem cell exosomes	Not applicable; n = 50	Hair diameters changed over time (time frame: 0 days, 1 month, 3 months, 6 months)	Active, not recruiting	China