Autologous and allogeneic mesenchymal stem cell-based therapies for diabetes mellitus: A systematic review and meta-analysis

Table 2 Detailed information about the characteristics of mesenchymal stem cells that are used in studies that underwent meta-analysis, and the various methods by which mesenchymal stem cells are grafted

Ref.	Source of MSCs	Type of graft of MSCs	Type of grafting method of MSCs	Targeted tissue/organ
Cai et al[12]	UC-MSCs and aBM-MNCs	Allogeneic	Intra-arterial infusion via supra-selective pancreatic artery cannulation	Pancreas
Packham et al[13]	BM-MPCs	Allogeneic	IV infusion	Kidneys
Carlsson et al[14]	BM-MSCs	Autologous	IV infusion	Pancreas
Leão et al[15]	ASCs	Allogeneic	IV infusion	Systemic administration
Skyler et al[16]	BM-MPCs	Allogeneic	IV infusion	Systemic administration
Thakkar et al[17]	IS-AD-MSCs and BM-HSCs	Autologous	Infusion into the portal vein, thymic circulation, and subcutaneous tissue	Pancreas and subcutaneous tissue
Zhao et al[18]	CB-SCs	Allogeneic	Stem cell educator therapy	Pancreas
			Re-infusion of educated lymphocytes into the patient’s circulation
Wu et al[19]	BM-MNCs	Autologous	Pancreatic intra-arterial infusion via the dorsal pancreatic artery	Pancreas
Wu et al[20]	BM-MSCs	Autologous	Intra-arterial and intravenous infusion	Pancreas

MSC: Mesenchymal stem cell; UC-MSCs: Umbilical cord-derived mesenchymal stem cells; aBM-MNCs: Autologous bone marrow mononuclear cells; BM-MPCs: Bone marrow-derived mesenchymal progenitor cells; BM-MSCs: Bone marrow-derived mesenchymal stem cells; ASCs: Adipose-derived mesenchymal stem cells; BM-MPCs: Bone marrow-derived mesenchymal progenitor cells; IV: Intravenous; IS-AD-MSCs: Adipose tissue derived insulin-secreting mesenchymal stem cells; BM-HSCs: Bone marrow-derived hematopoietic stem cells; CB-SCs: Cord-blood-derived multipotent stem cells; BM-MNCs: Bone marrow mononuclear cells.