Childhood insulin resistance and neural stem cell dysfunction in psychiatric disorders: Role of de novo lipogenesis and treatment perspectives

Table 2 Effects of selective adjunctive drugs/therapies on symptoms of psychosis and depression in patients with psychiatric disorders

Drugs/therapies	Psychosis1	Depression2
Aspirin	Reduced[122]	Reduced[130]
N-acetylcysteine	Reduced[123]	Reduced[131]
Minocycline	Reduced[122]	No effect[132]
Pregnenolone	Reduced[122]	Reduced[133]
Estrogens	Reduced[122,124]	Deteriorated[134]
Raloxifene	Reduced[122]	No effect[135]
Curcumin	Reduced[125]	Reduced[136]
Pioglitazone	Reduced[126]	Reduced[137]
Celecoxib	Reduced[127]	Reduced[138]
ω3-PUFAs	Reduced[128]	Reduced[139]
Aerobic exercise	Reduced[129]	Reduced[140]
Resistance exercise	May reduce[129]	Reduced [141]
MSC therapy	Unknown	Unknown

¹Measure of Positive and Negative Syndrome Scale score.

²Measure of Hamilton Depression Rating Scale total scores.

ω3-PUFAs: ω-3 polyunsaturated fatty acids; MSC: Mesenchymal stem cell.