Optimizing mesenchymal stem cell therapy for tendon-bone healing: Multifaceted approaches and future directions

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 12

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Stem Cells

ISSN

1948-0210

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Stem Cells. Dec 26, 2025; 17(12): 114076
Published online Dec 26, 2025. doi: 10.4252/wjsc.v17.i12.114076

Table 3 Limitations of mesenchymal stem cell therapy and main optimization strategies

Limitations	Strategies	Functions
Low delivery efficiency	Biomaterials	Sustained release of MSCs, reduced degradation, preventing cell leakage, and prolonging retention at the injury site
Limited direct differentiation potential	Preconditioning/gene modification	Enhancing MSC differentiation towards bone, cartilage, tendon, and other tissues
Limited cell functionality	Preconditioning/gene modification	Boosting MSC proliferation, migration, angiogenesis, and immune modulation capabilities
Immunogenicity	Exosomes	Acellular therapies that eliminate cellular immunogenicity

MSC: Mesenchymal stem cell.

Citation: Li H, Li ZP, Zhu MT, Lan CH, Wang YX, Liao P, Chen Z, Wang P, Sun JK, Shi Z, Lu PY, Lou C, Xu GH. Optimizing mesenchymal stem cell therapy for tendon-bone healing: Multifaceted approaches and future directions. World J Stem Cells 2025; 17(12): 114076
URL: https://www.wjgnet.com/1948-0210/full/v17/i12/114076.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i12.114076

Li H, Li ZP, Zhu MT, Lan CH, Wang YX, Liao P, Chen Z, Wang P, Sun JK, Shi Z, Lu PY, Lou C, Xu GH. Optimizing mesenchymal stem cell therapy for tendon-bone healing: Multifaceted approaches and future directions. World J Stem Cells 2025; 17(12): 114076 [PMID: 41480394 DOI: 10.4252/wjsc.v17.i12.114076]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.