Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p

doi:10.4252/wjsc.v17.i12.112207

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Dec 26, 2025; 17(12): 112207
Published online Dec 26, 2025. doi: 10.4252/wjsc.v17.i12.112207

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Figure 7 Hypoxic preconditioned human umbilical cord-derived mesenchymal stem cells derived exosomes alleviate H9C2 cells apoptosis and oxidative stress through the miR-486-5p targeting phosphoinositide 3-kinase/protein kinase B pathway. Akt: Protein kinase B; HUC-MSCs: Human umbilical cord-derived mesenchymal stems; PI3K: Phosphoinositide 3-kinase; PTEN: Phosphatase and tensin homolog.

Citation: Zeng ZF, Rao J, Xia XB, Chen XY, He HX, Liu B, Chen Q, Liu YD, Wang GJ, Cheng PC, Wang JN, Wang P, Yu Y, Wang ZN. Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p. World J Stem Cells 2025; 17(12): 112207
URL: https://www.wjgnet.com/1948-0210/full/v17/i12/112207.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i12.112207

Zeng ZF, Rao J, Xia XB, Chen XY, He HX, Liu B, Chen Q, Liu YD, Wang GJ, Cheng PC, Wang JN, Wang P, Yu Y, Wang ZN. Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p. World J Stem Cells 2025; 17(12): 112207 [PMID: 41480403 DOI: 10.4252/wjsc.v17.i12.112207]

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