Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p

Figure 6 Exosomal miR-486-5p activated the phosphoinositide 3-kinase/protein kinase B signaling pathway by phosphatase and tensin homolog inhibition. A-H: Expression of phosphatase and tensin homolog (PTEN) and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway protein was determined by western blotting (A and E). Quantitative analysis of the western blotting. All data are representative of three independent experiments and are presented as the mean ± standard error of the mean (n = 3). ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001.