Calcifying nanoparticles induce apoptosis and calcification in bone marrow mesenchymal stem cells via the transforming growth factor-β/Smad pathway

doi:10.4252/wjsc.v17.i12.106128

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 12

This Article

(60)

(44)

(0)

(13)

(781)

(1)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Stem Cells

ISSN

1948-0210

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Stem Cells. Dec 26, 2025; 17(12): 106128
Published online Dec 26, 2025. doi: 10.4252/wjsc.v17.i12.106128

Table 6 Protein expression of bone marrow mesenchymal stem cells treated with nanoscale hydroxyapatite and calcifying nanoparticles, mean ± SD

Protein	Control	M-nHAPs	M-CNPs	M-CNPs + SB431542
OPN	0.307 ± 0.014	0.463 ± 0.042^a	0.629 ± 0.047^a^,^b	0.471 ± 0.034^a^,^c
BMP-2	0.319 ± 0.035	0.411 ± 0.040^a	0.552 ± 0.031^a^,^b	0.398 ± 0.062^a^,^c
Bcl-2	0.684 ± 0.053	0.568 ± 0.059^a	0.446 ± 0.025^a^,^b	0.545 ± 0.036^a^,^c
Caspase3	0.370 ± 0.050	0.481 ± 0.043^a	0.673 ± 0.092^a^,^b	0.489 ± 0.050^a^,^c
BAX	0.364 ± 0.032	0.448 ± 0.035^a	0.527 ± 0.032^a^,^b	0.451 ± 0.024^a^,^c
TGF-β	0.383 ± 0.059	0.500 ± 0.054^a	0.638 ± 0.040^a^,^b	0.495 ± 0.055^a^,^c
Smad3	0.639 ± 0.034	0.687 ± 0.056^a	0.660 ± 0.025^a^,^b	0.683 ± 0.046^a^,^c
p-Smad3	0.721 ± 0.036	0.778 ± 0.041^a	0.877 ± 0.021^a^,^b	0.767 ± 0.041^a^,^c

^aP < 0.05 vs the control group.

^bP < 0.05 vs the medium concentration nanoscale hydroxyapatites group.

^cP < 0.05 vs the medium concentration calcifying nanoparticles group.

M-nHAPs: Medium concentration nanoscale hydroxyapatites; M-CNPs: Medium concentration calcifying nanoparticles; OPN: Osteopontin; BMP-2: Bone morphogenetic protein-2; TGF-β: Transforming growth factor-β.

Full Size Table

Citation: Su XL, Xu FR, Yang J, Niu SQ, Shi HJ, He YF, Li ZH, Bagari P, Wu XW, Peng XY, Zhang HW, Wang MY. Calcifying nanoparticles induce apoptosis and calcification in bone marrow mesenchymal stem cells via the transforming growth factor-β/Smad pathway. World J Stem Cells 2025; 17(12): 106128
URL: https://www.wjgnet.com/1948-0210/full/v17/i12/106128.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i12.106128

Su XL, Xu FR, Yang J, Niu SQ, Shi HJ, He YF, Li ZH, Bagari P, Wu XW, Peng XY, Zhang HW, Wang MY. Calcifying nanoparticles induce apoptosis and calcification in bone marrow mesenchymal stem cells via the transforming growth factor-β/Smad pathway. World J Stem Cells 2025; 17(12): 106128 [PMID: 41480401 DOI: 10.4252/wjsc.v17.i12.106128]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.