©The Author(s) 2025.
World J Stem Cells. Nov 26, 2025; 17(11): 113032
Published online Nov 26, 2025. doi: 10.4252/wjsc.v17.i11.113032
Published online Nov 26, 2025. doi: 10.4252/wjsc.v17.i11.113032
Figure 1 Mitochondria play a crucial role in regulating the osteogenic differentiation of mesenchymal stem cells through various mechanisms, including energy metabolism, oxidative stress regulation, mitochondrial dynamics, and autophagy.
ATP: Adenosine tripho sphate; OxPhos: Oxidative phosphorylation; TCA: Tricarboxylic acid; NF-κB: Nuclear factor kappa B; ROS: Reactive oxygen species; PI3K: Phosphoinositide 3-kinase; Akt: Protein kinase B; Wnt: Wingless/integrase; MSC: Mesenchymal stem cell; ER: Endoplasmic reticulum; PINK1: PTEN-induced kinase 1.
- Citation: Lu JS, Zhao YH, Mu FY, Song CY, Yang M, Huang YS, Wang KY. Mitochondrial regulation of stem cell osteogenic differentiation: A key driver for bone regeneration. World J Stem Cells 2025; 17(11): 113032
- URL: https://www.wjgnet.com/1948-0210/full/v17/i11/113032.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v17.i11.113032