Cancer cell-dependent increase in senescence-like populations following exosome treatment from bone marrow and induced pluripotent stem cell-derived mesenchymal stem cells

Figure 5 Invasion of PANC1 and MDA-MB-231 cells treated with exosomes. A and B: Representative images from the scratch assay illustrating wound closure in PANC1 (A) and MDA-MB-231 (B) cells treated with induced pluripotent stem cell-derived mesenchymal stem cell-derived exosomes or bone marrow mesenchymal stem cell-derived exosomes (scale bar = 200 μm); C and D: Quantitative analysis of wound area closure was conducted at 0 hour, 9 hours, and 48 hours post-scratch for PANC1 (C) and MDA-MB-231 (D) cells. Results are presented as mean ± SD. ^cP ≤ 0.001, ^dP ≤ 0.0001. iMSC-Exos: Exosomes derived from induced pluripotent stem cell-derived mesenchymal stem cells; BMSC-Exos: Exosomes derived from bone marrow mesenchymal stem cell; SFM: Serum-free medium.