Mesenchymal stem-derived exosomes enhance therapeutic benefits of exercise in isoproterenol-induced myocardial ischemia: Targeting ERK and Akt/mTOR signaling

Figure 8 Masson’s trichrome-stained longitudinal sections in the cardiac tissue. A: Control group: Fine collagen deposition (arrow) in-between cardiac muscle fibers (magnification 200 ×); B: ISO + MI group: Area of extensive fibrous tissue (star) besides scattered coarse collagen deposition (arrow) in-between the surrounding muscle fibers (magnification 200 ×); C: MI + EXE group: Scattered coarse collagen deposition (arrow) between the muscle fibers (magnification 200 ×); D: MI + MSC-EXO group a small area of minimal collagen deposition (arrow) (magnification 200 ×); E: MI + EXE + MSC-EXO group: A small area of minimal collagen deposition (arrow) (magnification 200 ×); F: The mean ± SD area% of collagen deposition. ^aP < 0.05, compared to the control group; ^bP < 0.05, compared to ISO + MI group; ^cP < 0.05, compared to MI + EXE and MI + MSC-EXO groups. MSC-EXO: Mesenchymal stem cell-derived exosomes.