Mesenchymal stem-derived exosomes enhance therapeutic benefits of exercise in isoproterenol-induced myocardial ischemia: Targeting ERK and Akt/mTOR signaling

Figure 5 Functional enrichment Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis and protein-protein interaction network. A: Pathway enrichment analysis of target genes; B: Diabetic cardiomyopathy signaling pathway as created by Kyoto Encyclopedia of Genes and Genomes database; C: Gene Ontology enrichment analysis of biological processes of target genes; D: A computational protein interaction analysis of studied proteins. The colored nodes denote the proteins, while the edges signify the protein-protein associations as shown in the legend section. The interacting nodes with hub protein kinase B represents the top ten predicted functional protein partners that include “sarcoplasmic/endoplasmic reticulum calcium ATPase2a”, “mitogen-activated protein kinase 1”, “matrix metalloproteinase”, “ephrin type-B receptor 2”, “mammalian target of rapamycin”, “ephrin-B2; cell surface transmembrane ligand for Eph receptors”, “ephrin-B3; cell surface transmembrane ligand for Eph receptors”, “heat shock protein HSP 90-beta”, “regulatory-associated protein of mammalian target of rapamycin”, and “TELO2-interacting protein 1 homolog”.