Synovial mesenchymal stem cell-derived exosomes delivering GRPEL1 activate PINK1-mediated mitophagy to promote cartilage repair in arthritis

Figure 2 Immune infiltration analysis and identification of mitochondria-related differentially expressed gene. A: Correlation between gene expression levels and 22 types of immune cells in the GSE169077 dataset; B: Venn diagram showing the overlap between shared differentially expressed genes (DEGs) and mitochondrial gene sets; C: Correlation analysis between mitochondria-related overlapping DEGs and significantly altered immune cell populations. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. OA: Osteoarthritis; DEGs: Differentially expressed genes; SERPINA5: Serine protease inhibitor 5; GRPEL1: GrpE-like 1; EFEMP1: Epidermal growth factor-containing fibulin extracellular matrix protein 1; BNIP3 L: Bcl2 interacting protein 3 Like; NK: Natural killer.