Melanoma cell adhesion molecule-positive mesenchymal stromal cells alleviate acute respiratory distress syndrome via nuclear factor kappa-B-mediated paracrine regulation

Figure 4 Therapeutic effects on acute respiratory distress syndrome after injection of CD146+ mesenchymal stromal cells and caffeic acid phenethyl ester pretreated CD146+ mesenchymal stromal cells. A and B: Comparison of body weight (A) and wet-dry ratio (B) of lung tissue across groups (n = 10 per group); C: White blood cell counts in bronchoalveolar lavage fluid were measured at the experimental endpoint (n = 10 per group); D and E: Representative images of pathological changes and lung injury scores (E) in the lung tissue of each group (n = 5 per group); F: Representative immunohistochemical images of VE-cadherin and zonula occludens-1 staining in different groups; G: H-scores of VE-cadherin and zonula occludens-1 in mouse lung tissues. The data are presented as the means ± SD and were analyzed via two-sided Student’s t tests.^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. WBC: White blood cell; MG: Model control (vehicle administered via caudal vein injection after establishing the acute respiratory distress syndrome model; MSC: Mesenchymal stromal cell; ZO-1: Zonula occludens-1.