Melanoma cell adhesion molecule-positive mesenchymal stromal cells alleviate acute respiratory distress syndrome via nuclear factor kappa-B-mediated paracrine regulation

Figure 2 CD146 protein expression in mesenchymal stromal cells cultured in medium from Shandong Qilu Cell Therapy Engineering Technology Co. Ltd., administered via caudal vein injection under the acute respiratory distress syndrome model. Variations in the expression of different proteins across various culture systems. Representative flow cytometry patterns from the different groups are shown. The expression of CD146 was significantly greater in the mesenchymal stromal cells cultured in medium from Shandong Qilu Cell Therapy Engineering Technology Co. Ltd., administered via caudal vein injection under the acute respiratory distress syndrome model system, whereas the CD271, CD106, vascular endothelial growth factor-2, and Nestin expression levels were not significantly different. NC: Negative control; DY: Mesenchymal stromal cells cultured in medium from Dakewe Biotech Co., administered via caudal vein injection after establishing the acute respiratory distress syndrome model; YF: Mesenchymal stromal cells cultured in medium from Shandong Qilu Cell Therapy Engineering Technology Co. Ltd., administered via caudal vein injection under the acute respiratory distress syndrome model; HK: Mesenchymal stromal cells cultured in medium from Cytoniche, administered via caudal vein injection in the acute respiratory distress syndrome model.