Human retinal secretome: A cross-link between mesenchymal and retinal cells

Table 3 Key molecules of the mesenchymal secretome derived from different cell types in the treatment and regeneration of retinal cells

MSC	MSC secretome	Müller glia cell secretome	RPE cell secretome	Other retinal cell secretome
IFN-γ[8]	IFN-γ[8]	TSP-1[131]	VEGF[68]	TSP-1[131]
VEGF[10]	VEGF[10]	PEDF[70]	TGF-β[69]	PEDF[70]
PIGF[81]	PIGF[81]	IL-1b[11]	PEDF[70]	IL-1b[11]
SDF-1[10]	SDF-1[10]	IL-1R[143]	MMPs[71]	IL-1R[143]
ANG2[10]	ANG2[10]	TNF-α[11]	NGF[72]	IL-6[11]
G-CSF[10]	G-CSF[10]	IL-4[134]	FGF-1[73]	TNF-α[11]
SCF[10]	SCF[10]	IL-6[134]	FGF-2[73]	IL-4[134]
PDGF[10]	PDGF[10]	IL-10[134]	FGF-5[73]	IL-10[134]
EGF[10]	EGF[10]	VEGF[10]	IGF-1[74]	VEGF[10]
HGF[10]	HGF[10]	IFN-γ[8]	BDNF[75]	IFN-γ[8]
IGF-1[10]	IGF-1[10]	TGF-β1[34]	PDGF[76]	TGF-β1[34]
TNF-α[11]	TNF-α[11]	TGF-β2[34]	CTGF[77]	TGF-β2[34]
IL-1b[11]	IL-1b[11]	TGF-β3[34]	LEDGF[78]	TGF-β3[34]
IL-2[11]	IL-2[11]	MMPs[71]	IL-1b[79]	MMPs[71]
IL-3[11]	IL-3[11]	CLU[121]	IL-2[79]	CLU[121]
IL-6[11]	IL-6[11]	SPP1[142]	IL-3[79]	SPP1[142]
IL-8[11]	IL-8[11]	BSG[142]	IL-6[79]	BSG[142]
CCL5[11]	CCL511	AQP4[143]	IL-8[79]	AQP4[143]
CCL2[11]	CCL2[11]	RLBP1[143]	TIMP[80]	RLBP1[143]
	TGF-β[18]	SLC1A3[143]	PIGF[81]	SLC1A3[143]
	FGF[18]	KCNJ1[143]	ANGIOGENIN[82]	KCNJ1[143]
	NGF-β[18]	KCNJ10[143]	EPO[83]	KCNJ10[143]
	CXCL12[19]	ANG2[143]	SOMATOSTATIN[84]	ANG2[143]
	miR-210[44]	ENDOGLIN[143]	APOA1[85]	ENDOGLIN[143]
	miR-200b-3p[44]	CXCL8[39]	APOE[116]	CXCL8[143]
	miR146a[46]	PDGF[10]	TGF-β[69]	PDGF[76]
	miR27a/b[46]	VAMP5[144]	BMP1[116]	VAMP5[144]
	miR-122-5p[46]		HTRA1[129]	TGF-β[69]
	miR-206[46]			NGF[72]
	MALAT[46] (lncRNA)			FGF-1[73]
				FGF-2[73]
				FGF-5[73]
				IGF-1[74]
				BDNF[75]
				PDGF[76]
				CTGF[77]
				LEDGF[78]
				IL-2[79]
				IL-3[79]
				IL-8[79]
				TIMP[80]
				PIGF[81]
				ANGIOGENIN[82]
				EPO[83]
				SOMATOSTATIN[84]
				APOA1[85]
				APOE[116]
				BMP1[116]
				HTRA1[129]

MSC: Mesenchymal stem cell; RPE: Retinal pigment epithelium; FGF: Fibroblast growth factor; NGF: Nerve growth factor.