Role of hypoxia preconditioning in therapeutic potential of mesenchymal stem-cell-derived extracellular vesicles

Table 2 Functional categories and annotations in Ingenuity Pathway Analyses of genes regulated by hypoxia-inducible factor 1A

Categories	P value	Top five functional annotations	Number of genes
Carbohydrate Metabolism	2.45E-12 to 2.81E-17	Quantity of carbohydrate, Uptake of D-glucose, Synthesis of polysaccharide, Glycolysis, Uptake of monosaccharide	44
Cardiovascular System Development and Function	1.00E-11 to 8.41E-31	Angiogenesis, Development of vasculature, Vasculogenesis, Endothelial cell development, Proliferation of endothelial cells	68
Cell Cycle	6.82E-12 to 4.39E-19	Mitogenesis, Binding of DNA, Interphase, Arrest in interphase, Cell cycle progression	53
Cell Death and Survival	1.08E-11 to 5.12E-36	Cell death of tumor cell lines, Apoptosis of tumor cell lines, Cell viability, Cell survival, Apoptosis	88
Cell Morphology	1.11E-11 to 4.76E-19	Tubulation of cells, Morphology of tumor cell lines, Autophagy of cells, Formation of cellular protrusions, Autophagy	67
Cell Signaling	6.16E-12 to 1.73E-12	Quantity of Ca2+, Synthesis of nitric oxide	29
Cell-To-Cell Signaling and Interaction	7.17E-12 to 1.36E-26	Activation of cells, Interaction of tumor cell lines, Binding of tumor cell lines, Activation of blood cells, Binding of professional phagocytic cells	62
Cell-mediated Immune Response	4.19E-14 to 7.70E-15	T cell development, T cell homeostasis	26
Cellular Assembly and Organization	1.74E-12 to 3.51E-20	Microtubule dynamics, Organization of cytoskeleton, Organization of cytoplasm, Development of cytoplasm	52
Cellular Development	1.10E-11 to 2.98E-39	Cell proliferation of tumor cell lines, Colony formation of cells, Proliferation of smooth muscle cells, Cell proliferation of carcinoma cell lines, Cell proliferation of breast cancer cell lines	89
Cellular Function and Maintenance	4.81E-13 to 6.37E-27	Cellular homeostasis, Lymphocyte homeostasis, Function of blood cells	63
Cellular Growth and Proliferation	8.67E-13 to 3.51E-27	Colony formation, Proliferation of connective tissue cells, Proliferation of vascular cells, Proliferation of lymphatic system cells, Proliferation of epithelial cells	72
Cellular Movement	9.45E-12 to 2.99E-30	Invasion of cells, Cellular infiltration, Cell movement of myeloid cells, Migration of cells, Cell movement of tumor cell lines	72
Connective Tissue Development and Function	1.56E-16 to 1.63E-25	Growth of connective tissue, Quantity of connective tissue cells, Quantity of connective tissue, Inflammation of joint, Rheumatic Disease	50
DNA Replication, Recombination, and Repair	4.08E-22	Synthesis of DNA	29
Digestive System Development and Function	1.42E-13	Morphology of digestive system	28
Embryonic Development	1.52E-12 to 1.2E-22	Development of body trunk, Development of abdomen, Growth of embryo, Formation of lymphoid tissue, Formation of lung	60
Free Radical Scavenging	3.11E-13 to 1.77E-17	Metabolism of reactive oxygen species, Synthesis of reactive oxygen species, Production of reactive oxygen species	29
Hair and Skin Development and Function	1.33E-13	Growth of skin	17
Hematological System Development and Function	1.17E-11 to 8.08E-21	Quantity of blood cells, Quantity of leukocytes, Quantity of lymphocytes, Quantity of myeloid cells, Quantity of T lymphocytes	52
Inflammatory Response	9.18E-22 to 4E-24	Inflammation of absolute anatomical region, Inflammatory response, Inflammation of body cavity	59
Lipid Metabolism	8.00E-12 to 3.77E-16	Concentration of lipid, Synthesis of lipid	41
Lymphoid Tissue Structure and Development	3.73E-18	Quantity of lymphatic system cells	35
Molecular Transport	7.49E-15	Transport of molecule	44
Nervous System Development and Function	4.54E-12	Sensory system development	22
Organ Development, Renal and Urological System Development	8.50E-12 to 3.25E-12	Growth of kidney, Growth of renal glomerulus	11
Organ Morphology	1.78E-13	Morphology of gland	22
Organismal Development	1.92E-12 to 7.70E-25	Morphology of body cavity, Formation of vessel, Morphology of head, Development of genitourinary system, Growth of organism	73
Organismal Survival	7.68E-26 to 1.24E-28	Organismal death, Survival of organism	75
Post-Translational Modification	4.05E-12 to 1.23E-15	Phosphorylation of protein, Activation of protein	31
Skeletal and Muscular System Development and Function	1.08E-11 to 1.22E-26	Morphology of muscle, Function of muscle, Growth of smooth muscle	39
Tissue Development	1.73E-13 to 3.23E-30	Development of epithelial tissue, Growth of epithelial tissue, Growth of nervous tissue, Accumulation of cells, Formation of epithelial tissue	58
Tissue Morphology	3.33E-14 to 2.65E-24	Quantity of cells, Quantity of progenitor cells	60