Human amniotic fluid stem cell therapy can help regain bladder function in type 2 diabetic rats

doi:10.4252/wjsc.v14.i5.330

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. May 26, 2022; 14(5): 330-346
Published online May 26, 2022. doi: 10.4252/wjsc.v14.i5.330

Table 2 Blood glucose and body and bladder weight in different groups

	Group (n = 6), [median (Q1, Q3)]	Body weight (initial; gm)	Body weight (final; gm)	Blood glucose (initial; mg/dL)	Blood glucose (final; mg/dL)	Bladder weight (mg)
4 wk	Normal control	244.45 (238.53, 250.68)	305.30 (290.00, 312.00)	136.00 (125.00, 137.00)	132.50 (123.00, 141.25)	167.50 (148.75, 185.00)
	HFD control	235.60 (232.90, 240.65)	339.00 (331.30, 353.63)	144.00 (132.00, 147.00)	161.00 (146.00, 166.00)	147.50 (141.25, 152.50)
	DM	250.30 (243.40, 251.43)	288.80 (287.30, 301.00)	136.50 (131.75, 145.75)	452.50 (434.75, 466.75)^a^,^b	210.00 (205.00, 213.75)^b
	DM + insulin	235.50 (233.95, 243.95)	325.70 (295.93, 328.63)	141.50 (130.25, 144.50)	229.00 (213.00, 245.50)	120.00 (120.00, 135.00)^c
	DM + hAFSCs	241.00 (228.60, 244.20)	296.90 (276.00, 299.90)	140.00 (136.50, 146.50)	409.00 (377.00, 423.00)^a^,^b	200.00 (192.50, 206.25)^d
	P value	0.551	0.082	0.881	0.001	0.001
12 wk	Normal control	255.95 (250.63, 258.65)	336.00 (326.10, 364.90)	141.50 (136.25, 143.00)	155.50 (148.75, 161.50)	170.00 (165.00, 175.00)
	HFD control	249.25 (239.35, 252.25)	380.10 (366.00, 417.40)	147.00 (129.00, 148.00)	158.50 (150.25, 168.25)	130.00 (115.00, 140.00)
	DM	244.20 (238.50, 248.90)	278.50 (277.30, 286.20)^a^,^b	148.00 (115.00, 157.00)	394.00 (378.00, 408.00)^a^,^b	205.00 (190.00, 210.00)^b
	DM + insulin	247.10 (242.03, 257.65)	333.20 (304.83, 351.98)	142.50 (133.75, 145.25)	223.50 (210.00, 257.75)	130.00 (126.25, 133.75)^c
	DM + hAFSCs	248.40 (239.60, 253.70)	278.60 (260.10, 279.30)^a^,^b^,^d	138.00 (133.00, 142.75)	374.00 (359.00, 390.50)^a^,^b	187.50 (183.75, 190.00)^b^,^d
	P value	0.756	0.001	0.973	< 0.0001	< 0.0001

^aP < 0.05 vs normal control (4 wk and 12 wk).

^bP < 0.05 vs high-fat diet control (4 wk and 12 wk).

^cP < 0.05 vs diabetes (4 wk and 12 wk).

^dP < 0.05 vs diabetes + insulin (4 wk and 12 wk).

Initial body weight: Body weight measured before therapy. Final body weight: Body weight measured at 4 wk and 12 wk after therapy. Initial body glucose: Body glucose measured before therapy. Final body glucose: Body glucose measured at 4 wk and 12 wk after therapy. Bladder weight: Bladder weight measured at 4 wk and 12 wk after therapy. Statistical methods: Kruskall-Wallis test. P < 0.05 was regarded as significant. DM: Diabetes mellitus; hAFSCs: Human amniotic fluid stem cells; HFD: High-fat diet.

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Citation: Liang CC, Shaw SW, Huang YH, Lee TH. Human amniotic fluid stem cell therapy can help regain bladder function in type 2 diabetic rats. World J Stem Cells 2022; 14(5): 330-346
URL: https://www.wjgnet.com/1948-0210/full/v14/i5/330.htm
DOI: https://dx.doi.org/10.4252/wjsc.v14.i5.330

Liang CC, Shaw SW, Huang YH, Lee TH. Human amniotic fluid stem cell therapy can help regain bladder function in type 2 diabetic rats. World J Stem Cells 2022; 14(5): 330-346 [PMID: 35722197 DOI: 10.4252/wjsc.v14.i5.330]

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