First immunohistochemical evidence of human tendon repair following stem cell injection: A case report and review of literature

Table 2 Histological and immunohistochemical features of different regions within the second part of the biopsy that was investigated in this study

Feature	Region in Figure 4						Figure
	B	C	D	E	F	G
Presence of microvessels	++	-	+++	+/-	-	-	4
Dense, unorganized cluster of cells and microvessels	-	-	+++	-	-	-	4
Elongated cells in a chain-like arrangement	-	-	-	++	+	+++	4
Immunohistochemical detection of
CD34 in capillary endothelial cells	-	-	++	-	+++	+	5
Type IV collagen in the basement membrane of microvessels	+	-	+++	+++	+	+	6
Ki-67 in cells inside microvessel walls	+/-	-	+++	-	-	-	7
Ki-67 in cells outside microvessel walls	-	+/-	+++	-	+++	-	7
Intracellular tenomodulin	+	-	+++	+/-	-	-	8
Extracellular tenomodulin	-	-	+++	-	-	-	8
Type I procollagen	-	+/-	+++	+++	+++	+	9
Unorganized type I collagen	+/-	-	+++	+++	-	-	10
Organized, slightly undulating Type I collagen	-	-	-	+/-	++	+++	10
Type III collagen	+	+/-	+	+	-	-	11
Intracellular laminin	+/-	+/-	+++	+++	+	+	12
Extracellular laminin	-	-	+++	+	-	-	12
Intracellular MMP-2	+/-	+/-	+++	++	++	+	13
Extracellular MMP-2	-	-	+++	++	+++	+	13
Intracellular MMP-9	+/-	+/-	+/-	-	+/-	+/-	14
Extracellular MMP-9	-	-	-	-	-	-	14
CD68	+/-	+/-	++	+	+/-	+/-	15

Absence or presence of individual features is coded as – (absence), +/- (minimal presence), + (slight presence), ++ (significant presence) and +++ (overwhelming presence). Column "Figure" indicates the corresponding figures in which detailed documentation is provided. MMP: Matrix metalloproteinase. CD: Cluster of differentiation; MMP: Matrix metalloproteinase.