Multidifferentiation potential of dental-derived stem cells

Table 2 Summary of the long noncoding RNAs influencing the odontogenic/osteogenic differentiation of dental mesenchymal stem cells

Ref.	LncRNA	Cell type	Signaling pathway or targets	Outcome
Liu et al[141], 2020	lncRNA SNHG7	DPSCs	miR-1226-3p, miR-210-5p	Downregulation inhibited osteo/odontogenic differentiation
Chen et al[142], 2020	lncRNA-G043225	DPSCs	miR-588, FBN1	Positively regulated odontoblastic differentiation
Zhong et al[145], 2019	lncRNA CCAT1	DPSCs	miR-218	Overexpression promoted odontogenic differentiation
Zeng et al[146], 2018	lncRNA H19	DPSCs	DLX3	Upregulation enhanced odontogenic differentiation
Shi et al[143], 2019	lncRNA STL	DPSCs	-	Knockdown inhibited osteogenesis
Tao et al[147], 2019	lncRNA XIST	DPSCs	-	Downregulation inhibited osteogenic differentiation
Zheng et al[149], 2018	lncRNA MEG8, lncRNA MIR22HG	PDLSCs	-	Downregulation suppressed osteogenic differentiation
Liu et al[150], 2019; Deng et al[151], 2018	lncRNA MEG3	PDLSCs	miR-27a-3p/IGF1 axis, Wnt/β-catenin	Knockdown inhibited osteogenesis
Wang et al[152], 2016	lncRNA-POIR	PDLSCs	miR-182	Enhanced osteogenic differentiation
Xu et al[153], 2019	lncRNA-TWIST1	PDLSCs	TWIST1	Improved osteogenic differentiation
Jia et al[154], 2019	lncPCAT1	PDLSCs	-	Reversed the suppression effect of osteogenesis caused by miR-106a-5p overexpression
Huang et al[155], 2020	lncRNA FER1L4	PDLSCs	miR-874-3p	Promoted osteogenic differentiation
Feng et al[156], 2020	lncRNA XIST	PDLSCs	miR-214-3p	Enhanced osteogenic differentiation
He et al[160], 2018	lncRNA TUG1	PDLSCs	lin-28 homolog A	Improved osteogenic differentiation
Wang et al[161], 2020	lncRNA DANCR	PDLSCs	-	Positively regulated osteogenic differentiation
Li et al[162], 2019	lncRNA H19	SCAPs	lncRNA-H19/miR-141/SPAG9/MAPK	Promoted the osteo/odontogenesis
Jia et al[157], 2016; Jia et al[158], 2015; Peng et al[159], 2018	lncRNA ANCR	DPSCs, PDLSCs, SCAPs	Wnt, lncRNA-ANCR/miR-758/Notch2 (PDLSCs)	Downregulation facilitated osteogenic differentiation

DPSCs: Dental pulp stem cells; FBN1: Fibrillin 1; lncRNAs: Long noncoding RNAs; MAPK: Mitogen-activated protein kinases; MEG3/8: Maternally-expressed 3/8; miR: MicroRNA; IGF1: Insulin-like growth factor 1; PDLSCs: Periodontal ligament stem cells; SCAPs: Stem cells from apical papilla; XIST: X-inactive specific transcript.