Basic Study
Copyright ©The Author(s) 2021.
World J Stem Cells. Dec 26, 2021; 13(12): 1928-1946
Published online Dec 26, 2021. doi: 10.4252/wjsc.v13.i12.1928
Figure 9
Figure 9 Schematic of protective effects of Urolithin A. Urolithin A activates the SIRT1/PGC-1α signaling pathway to protect mitochondrial function, alleviate nucleus pulposus-derived mesenchymal stem cells senescence in vitro, and delay intervertebral disc degeneration in vivo. SIRT1/PGC-1α: Silent information regulator of transcription 1/PPAR gamma coactivator-1α; NPMSCs: Nucleus pulposus-derived mesenchymal stem cells; UA: Urolithin A.