Priming strategies for controlling stem cell fate: Applications and challenges in dental tissue regeneration

Figure 1 Overview of the functional improvements of mesenchymal stromal cell (MSC) properties by priming strategies. MSCs can be primed via different approaches, such as priming culture conditions, pretreatment with mechanical and physical stimuli, preconditioning with cytokines and growth factors, and genetic modification. As promising outcome, primed MSCs can exhibit prolonged therapeutic efficacy, including migration, anti-apoptosis, anti-inflammation, immunomodulation, proangiogenesis, and regenerative properties. The improved capabilities are interconnected and greatly influenced by priming approaches.