Review
Copyright ©The Author(s) 2020.
World J Stem Cells. Jul 26, 2020; 12(7): 545-561
Published online Jul 26, 2020. doi: 10.4252/wjsc.v12.i7.545
Table 1 Biofunctionlization of orthopaedic implant with bioactive ceramic to regulate bone marrow mesenchymal stem cell behavior
MethodPreparation of bioactive ceramicCell responseRef.
Plasma sprayingTiO2-HA nanocomposite powders were thermally sprayed via the HVOF (high-velocity oxy-fuel) technique.HBMSCs have stronger initial adhesion and favor osteogenic differentiation.Dimitrievska et al[26]
Ta-incorporated HA coatings were fabricated using the plasma spray technique on a titanium substrate.Ta-incorporated HA coating could promote initial adhesion, faster proliferation, and osteogenic differentiation of BMSCs.Lu et al[28]
An atmosphere plasma spray system was applied to spray the synthesized 40-80 μm powders onto the treated substrates.The attachment and proliferation of BMSCs were more significantly on akermanite coatings than on HA coatings.Yi et al[31]
Sol-gel methodTi disks were etched with the mixed solution of HF and H2SO4. Next, EtOH solutions containing tetrabutyl titanate (TBT) were spin-coated onto samples.The micro/nano-level structure of large particles (80 nm) significantly promoted MSC proliferation and differentiation.Shen et al[23]
Pre-hydrolyzed silica solution was added to a solution containing the pores structure-directing agents dissolved in ethanol.The silica coatings accelerate the adhesive response of early BMSCs and promote BMSC osteogenic differentiation.Inzunza et al[34]