Stem cell homing, tracking and therapeutic efficiency evaluation for stroke treatment using nanoparticles: A systematic review

Table 5 Stroke models induced by filament intraluminal middle cerebral artery, brain injury evaluation and animal features

Ref.	Ischemia mechanism	Animals					n / N	Ischemia type	Ischemia time (min)	Filament type	Anesthesia	Brain induction area (AP; ML to bregma in mm)	Blood flow analysis	Injury evaluation
		Specie	Type	Sex	Weight (g)	Age (wk)
Yun et al[30]	MCAo	Rat	SD	M	240-260	Adult1	3-8/50	T	30	3-0 nylon suture	NR	MNI	NI	TTC, MRI
Argibay et al[38]	MCAo	Rat	Wistar	M	280-300	NR	6/133	T	45	silicon rubber-	3%-4% sevoflurane	MNI	Laser-Doppler	MRI
Duan et al[37]	MCAo	Rat	SD	M	250-280	Adult1	6/54	NR	NR	NR	NR	MNI	NI	MRI
Lu et al[35]	MCAo	Rat	SD	NR	NR	NR	6/12	T	90	4-0 nylon suture, silicone coated tip	1% halothane	MNI	NI	MRI
Zhang et al[34]	MCAo	Rat	SD	NR	250-280	Adult1	NR/30	T	120	NR	PB (40 mg/kg)	MNI	NI	MRI
Lin et al[36]	MCAo	Rat	SD	M	250-280	Adult1	6/18	T	120	NR	NR	MNI	NI	MRI
Zhang et al[39]	MCAo	Mice	C57BL/6J	NR	20-25	8	NR/45	T	20	Nylon poly-1-lysinecoated	PB (6 mL/kg)	MNI	NI	MRI
Duan et al[40]	MCAo	Rat	SD	M	NR	Adult1	NR/24	NR	NR	NR	NR	MNI	NI	MRI
Chen et al[28]	MCAo	Mice	C57BL/6J	M	25-30	Adult1	NR/NR	T	120	square knot using a 10 suture	CH (0.4 g/kg)	zygoma/squamosal bone	NI	MRI
Tan et al[41]	Lacunar infarction	Rat	Wistar	M	240-260	NR	NR/22	P	NA	NA	2%-4% ISO	0; 3	NI	MRI
Zhang et al[45]	MCAo	Mice	CD1	F	NR	4	NR/NR	P	NA	6-0 rounded tip nylon	NR	MNI	NI	MRI
Park et al[43]	MCAo	Rat	SD	NR	250-280	NR	8/16	T	120	Micro clip 24 mm	Rompum (10 mg/kg) + Zoletil (30 mg/kg)	MNI	NI	MRI
Liu et al[47]	MCAo	Rat	SD	M	160-180	NR	6-8/48	NR	NR	Nylon	10% CH (300 mg/kg)	MNI	NI	MRI
Wang et al[48]	MCAo	Mice	CD1	F	NR	4	7/21	T	180	6-0 rounded tip nylon	NR	NI	NI	MRI
Song et al[49]	MCAo	Rat	SD	M	250-300	NR	3/6	T	120	NR	4% ISO	MNI	NI	MRI
Kim et al[51]	MCAo	Rat	SD	M	250-300	NR	2-6/13	P	NA	NR	ket. (80-100 mg/kg) + AM (5 mg/kg)	MNI	EEG	MRI
Guzman et al[52]	MCAo	Rat	SD	M	NR	Adult1	5/10	P	NA	NA	ISO	MNI + rhinal fissure	NI	MRI
	Global	Mice	NOD-SCID	NR	NR	0-1PN	12-16/28	T	5-10	NA	Cryoanestrhetized	NA	NI	MRI

¹Adult: Rat with 8-16 wk and mice with 6 to 20 wk. MCAo: Middle cerebral artery occlusion; SD: Sprague-Dawley; CD1: An outbred mice derived from a group of outbred Swiss mice; NOD/SCID: Nonobese diabetic/severe combined immunodeficiency; M: Male; F: Female; NR: No reported; n/N: Number of animals per group/total number of animals; T: Transient; P: Permanent; PN: Postnatal; NA: Not applicable; Ket: Ketamine; Xyl.: Xylamine; ISO: Isoflurane; AM: Aceprozazine maleate; CH: Chloral hydrate; PB: Pentobarbital; MNI: Midline neck incision; EEG: Electroencephalogram; TTC: Triphenyltetrazolium chloride; MRI: Magnetic resonance imaging.