C-C chemokine receptor type 2-overexpressing exosomes alleviated experimental post-stroke cognitive impairment by enhancing microglia/macrophage M2 polarization

Figure 3 Exo^CCR2 exerts superior beneficial effects on remyelination and oligodendrogenesis at day 28 after transient middle cerebral occlusion compared to Exo^Ctrl. A, B: Western blotting analysis of the MBP expression in samples from rats in each group. n = 5, ^aP < 0.05, ^bP < 0.01, ^cP < 0.001; C, D: Analysis of MBP fluorescence intensity in samples from rats in each group. Scale bar = 50 μm, n = 6, ^aP < 0.05, ^bP < 0.01, ^cP < 0.001; E, F: NG2+/ BrdU+ cell colocalization count by immunofluorescence staining. Scale bar = 50 μm, n = 6. ^bP < 0.01, ^cP < 0.001.