Copyright
©The Author(s) 2020.
World J Stem Cells. Feb 26, 2020; 12(2): 100-109
Published online Feb 26, 2020. doi: 10.4252/wjsc.v12.i2.100
Published online Feb 26, 2020. doi: 10.4252/wjsc.v12.i2.100
Table 3 Exosomes derived from umbilical cord mesenchymal stem cells
| Condition | In vitro study | In vivo study (animal model / clinical use) | Results | Ref. |
| Cutaneous wound healing | + | Wound model (Rat) | Proangiogenic effect | Zhang et al[42], 2015 |
| Bone healing | + | Femoral fracture model (Rat) | Accelerated fracture healing via the promotion of angiogenesis | Zhang et al[43], 2019 |
| Bone healing | - | Fracture model (Rat) | Repairs fractures in rats through the Wnt signaling pathway | Zhou et al[44], 2019 |
| Inflammatory bowel disease | + | Inflammatory bowel disease model (Mouse) | Alleviates induced inflammatory bowel disease | Mao et al[45], 2017 |
| Acute liver failure | + | Liver injury model (Mouse) | Decreases acute liver failure in that model | Jiang et al[49], 2019 |
| Colitis | + | Colitis model (Mouse) | Improves colon damage in an animal disease model and has immunosuppressive effects in vitro | Ma et al[46], 2019 |
| Autoimmune uveitis | + | Autoimmune uveitis model (Rat) | Ameliorates autoimmune uveitis by inhibiting the migration of inflammatory cells | Bai et al[47], 2017 |
| Idiopathic macular hole | - | Clinical patients (5) | May improve anatomic and visual outcomes of surgery for that disease | Zhang et al[48], 2018 |
| Myocardial infarction | + | Myocardial infarction model (Rat) | UcMSC-Ex encapsulated in a functional peptide hydrogel could be effective for cardiac regeneration | Han et al[50], 2019 |
- Citation: Álvarez-Viejo M. Mesenchymal stem cells from different sources and their derived exosomes: A pre-clinical perspective. World J Stem Cells 2020; 12(2): 100-109
- URL: https://www.wjgnet.com/1948-0210/full/v12/i2/100.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v12.i2.100