Bone marrow microenvironment: The guardian of leukemia stem cells

doi:10.4252/wjsc.v11.i8.476

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Aug 26, 2019; 11(8): 476-490
Published online Aug 26, 2019. doi: 10.4252/wjsc.v11.i8.476

Table 3 Chronic myeloid leukemia and acute myeloid leukemia stem cell markers for detection and selective targeting

Target	CD	CML LSC	AML LSC	Normal HSC	Normal progenitor	Ref.
IL-2Rα	CD25	+	+	-	+/-	[59,69]
DPP4	CD26	+	-	-	-	[16]
Siglec-3	CD33	+	+	+	+	[98]
SCARB3	CD36	+	+	+/-	+	[99]
Pgp-1	CD44	+	+	+	+	[38]
IAP	CD47	+	+	+	+	[70]
Campath-1	CD52	+	+	+	+	[100]
C1qR1	CD93	+	+	+/-	+/-	[101]
Tactile	CD96	-	+	-	-	[66]
MIC2	CD99	-	+	+	+	[102]
SCFR	CD117	+	+	+/-	+/-	[64]
IL-3Rα	CD123	+	+	+/-	+/-	[68]
CLL-1	-	+/-	+	+/-	+	[67]
TIM-3	-	-	+	+/-	+/-	[71]
IL-1RAP	-	+	+	-	+	[60,103]

CML LSC: Chronic myeloid leukemia stem cells; AML LSC: Acute myeloid leukemia stem cell; HSC: Hematopoietic stem cell; IL-2Rα: Interleukin-2 receptor alpha; DPP4: Dipeptidyl peptidase 4; Siglec-3: Sialic acid-binding immunoglobulin-type lectin-3; SCARB3: Mast/stem cell growth factor receptor; IL-3Rα: Interleukin receptor subunit α; CLL-1: C-type lectin-like molecule-1; TIM-3: T-cell immunoglobulin mucin-3; IL-1RAP: Interleukin-1 receptor accessory protein.

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Citation: Houshmand M, Blanco TM, Circosta P, Yazdi N, Kazemi A, Saglio G, Zarif MN. Bone marrow microenvironment: The guardian of leukemia stem cells. World J Stem Cells 2019; 11(8): 476-490
URL: https://www.wjgnet.com/1948-0210/full/v11/i8/476.htm
DOI: https://dx.doi.org/10.4252/wjsc.v11.i8.476

Houshmand M, Blanco TM, Circosta P, Yazdi N, Kazemi A, Saglio G, Zarif MN. Bone marrow microenvironment: The guardian of leukemia stem cells. World J Stem Cells 2019; 11(8): 476-490 [PMID: 31523368 DOI: 10.4252/wjsc.v11.i8.476]

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