Similarities and differences between mesenchymal stem/progenitor cells derived from various human tissues

Figure 3 Fluorescence intensity positive for MSC markers CD73 (APC), CD90 (FITC), CD105 (PE), and CD146 (PE) in bone marrow - mesenchymal stem cells, adipose tissue - mesenchymal stem cells, and skin - mesenchymal stem cells, and CD56 (PE) only in skeletal muscle - mesenchymal stem cells. Heterogeneous population isolated from skeletal muscles showed the strongest instability of naïve MSC markers. Expression of CD73 and CD90 was preserved among the MSCs isolated from other tissues (BM, AT, and SK); however, fluorescence intensity decreased in AT-MSCs and SK-MSCs in the later passages. Expression of the CD105 marker was the most varied during the follow-up period. Fluorescence intensity of the proangiogenic marker CD146 was the strongest in BM-MSCs and AT-MSCs in the early passages. BM-MSC: Bone marrow - mesenchymal stem cell; AT-MSC: Adipose tissue - mesenchymal stem cell; SK-MSC: Skin - mesenchymal stem cell; SM-MSC: Skeletal muscle - mesenchymal stem cell.