Improved guided bone regeneration by combined application of unmodified, fresh autologous adipose derived regenerative cells and plasma rich in growth factors: A first-in-human case report and literature review

Figure 5 Histological findings. Representative photomicrographs of 3 µm thick paraffin sections stained with hematoxylin and eosin of biopsies that were collected at 6 wk (A, B, E, F) or 34 wk (C, D, G, H) after guided bone regeneration maxillary sinus augmentation with the application of UA-ADRCs (A, C, E, G) or without UA-ADRCs (B, D, F, H). In A-D the asterisks indicate newly formed bone and the arrows indicate empty osteocyte lacunae in allogeneic fragments. Furthermore, in A and B the arrowheads point to osteoblasts with underlying osteoid, while in C and D the arrowheads indicate adipocytes. In E-H the arrows indicate cells on the surface of newly formed bone. The scale bar in H represents 150 µm in A-D and 75 µm in E-H. UA-ADRCs: Unmodified autologous adipose-derived regenerative cells.