Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies

doi:10.4252/wjsc.v11.i11.920

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Nov 26, 2019 (publication date) through May 8, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Nov 26, 2019; 11(11): 920-936
Published online Nov 26, 2019. doi: 10.4252/wjsc.v11.i11.920

Table 3 Positive correlation between combined expression of cancer stem cell markers CD133, CD44 and CD166 and epigenetic erasers

Family/gene symbol	Putative epidrug/chemical probe	Z-score	P value
DNA demethylation
TET2	-	5.968	2.40E-09
Histone demethylation
LSD family of demethylases
	ORY-1001³, (±)-tranylcypromine³
KDM3B		5.636	1.74E-08
KDM4B	CP2³[90]	5.212	1.87E-07
KDM4C	CP2³[90]	3.895	9.81E-05
KDM5B	CPI-455³, AS-8351³, 59³ (KDOAMA-25³)[90]	9.092	9.72E-20
KDM6A	GSK-J1³	2.84	0.00451
KDM6B	GSK-J1³	4.014	5.98E-05

¹Approved for the treatment of other diseases; ²Used in clinical trials for other diseases;

³Not yet used in clinical trials.

Citation: Vincent A, Ouelkdite-Oumouchal A, Souidi M, Leclerc J, Neve B, Van Seuningen I. Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies. World J Stem Cells 2019; 11(11): 920-936
URL: https://www.wjgnet.com/1948-0210/full/v11/i11/920.htm
DOI: https://dx.doi.org/10.4252/wjsc.v11.i11.920