Unmodified autologous stem cells at point of care for chronic myocardial infarction

Figure 3 Steady-state free precession CMR imaging of the porcine heart. A-D: Representative examples of end-systolic, short axis, transversal images through the mid left ventricle of a porcine heart obtained with SSFP CMR imaging for analyzing hemodynamic parameters and wall motility at time points T1 (A, C) and T2 (B, D) of a representative animal in group 1 (delivery of UA-ADRCs) (A, B) and a representative animal in group 2 (control) (C, D) (details are provided in the main text). In all panels, the epicardial contours are highlighted in green, and the endocardial contours in red. Note the increased end-systolic thickness of the left ventricular wall at T2 after delivery of UA-ADRCs at T1 (asterisks in B) compared to the delivery of saline at T1 (D). In the examples presented here, the left ventricular ejection fraction was 27.2% in (A), 39.7% in (B), 22.5% in (C), and 27.2% in (D). CMR: Cardiac magnetic resonance; SSFP CMR: Steady-state free precession cardiac magnetic resonance; UA-ADRCs: Fresh, uncultured, unmodified, autologous adipose-derived regenerative cells.