Unmodified autologous stem cells at point of care for chronic myocardial infarction

Table 1 Results of statistical analysis

Parameter	Group 1 (delivery of UA-ADRCs)				Group 2 (delivery of saline as control)				P values of repeated measures two-way analysis of variance
	T1		T2		T1		T2
	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM	I	Time	Tr	SM
LVEF	343	289	404	264	378	257	362	245	0.036	0.207	0.912	0.006
CO	273	022	378	023	339	030	363	032	0.049	0.004	0.458	0.019
SV	314	202	443	239	346	299	380	343	0.036	0.001	0.638	0.048
EDV	936	507	1119	624	926	645	1061	717	0.358	< 0.001	0.696	< 0.001
ESV	621	528	676	649	580	524	681	603	0.327	0.005	0.821	< 0.001
HR	870	293	854	419	974	396	955	361	0.940	0.400	0.051	0001
MLV	553	499	713	449	632	335	684	397	0.042	0.001	0.665	0.001
ScVol	209	229	166	119	176	138	227	176	0.002	0.739	0.509	0.019

The time points T1 and T2 are explained in detail in the main text. P values < 0.05 are given boldface. T1: Delivery of UA-ADRCs (group 1) or saline (group 2) 4 wk after induction of myocardial infarction; T2, 6 wk after T1 (i.e. 10 wk after induction of myocardial infarction); LVEF: Left ventricular ejection fraction (%) (primary objective); CO: Cardiac output (L/min); SV: Stroke volume (mL); EDV: End diastolic volume (mL); ESV: End systolic volume (mL); HR: Heart rate (min^-1); M_LV: Left ventricular mass (g); ScVol: Relative amount of scar volume of the left ventricular wall (%); I: Interaction; Tr: Treatment; SM: Subject matching; UA-ADRCs: Fresh, uncultured, unmodified autologous adipose-derived regenerative cells.