基于16S rRNA序列分析肠道菌群失调与溃疡性结肠炎的相关性

表2 溃疡性结肠炎组和健康对照组在不同代谢通路中肠道微生物丰度差异

代谢通路	UC组		对照组		P值
	平均丰度	标准差	平均丰度	标准差
Signal Transduction
Phosphatidylinositol signaling system	0.1022	0.0155	0.0845	0.0182	0.019
Biosynthesis of Other Secondary
Metabolites;Isoflavonoid biosynthesis	8.97×10-6	8.03×10-6	9.75×10-7	1.39×10-7	0.003
Novobiocin biosynthesis1	0.1161	0.01	0.1277	0.0122	0.025
Lipid Metabolism
Linoleic acid metabolism	0.0851	0.0505	0.0518	0.0197	0.025
Primary bile acid biosynthesis	0.0416	0.0186	0.0257	0.012	0.019
Secondary bile acid biosynthesis	0.0414	0.0187	0.0255	0.012	0.018
Nucleotide Metabolism
Purine metabolism	2.2171	0.2176	2.0283	0.1561	0.018
Xenobiotics Biodegradation and Metabolism
Ethylbenzene degradation	0.0769	0.0643	0.0429	0.00795	0.018
Naphthalene degradation	0.1827	0.0823	0.13	0.0261	0.018
Nitrotoluene degradation1	0.0651	0.0346	0.1022	0.0198	0.025
Styrene degradation1	0.0155	0.0131	0.0329	0.0231	0.025

¹UC组别在该通路平均丰度比对照组高(P<0.05). UC: 溃疡性结肠炎.