Brief Reports
Copyright ©The Author(s) 2003.
World J Gastroenterol. Aug 15, 2003; 9(8): 1836-1839
Published online Aug 15, 2003. doi: 10.3748/wjg.v9.i8.1836
Table 2 Point estimates and 95%CIs of the risk difference of death
Prapranolol group
Control group
Risk difference and its 95%CI (%)
TotalDeathTotalDeath
Primary prevention
Pascal (1984)3413513-34 [-51, -17]
Mills (1987)38154319-5 [-26, 17]
Pascal (1987)1182511240-15 [-26, -3]
Italian (1988)8530892211 [-3, 24]
Strauss (1988)207167-9 [-41, 23]
Colman (1990)236257-2 [-27, 23]
Andreani (1990)43134118-14 [-34, 7]
Conn (1991)5185111-6 [-21, 9]
Prova (1991)6877214-9 [-21, 3]
Subtotal480112484151-9 [-18, -1]
Overall effectZ = -2.11P = 0.03
Secondary prevention
Burroughs (1983)264225-7 [-30, 15]
Lebrec (1984)383368-14 [-30, 2]
Cerbelaud (1986)4254212-17 [-33, 0]
Villeneuve (1986)421937147 [-14, 29]
Queuniet (1987)51124813-4 [-21, 14]
Marbet (1988)101103-20 [-54, 14]
Colombo (1989)324307-11 [-30, 8]
Sheen (1989)180182-11 [-28, 6]
Garden (1990)38144319-7 [-29, 14]
Colman (1990)2612610 [-10, 10]
Perez-Ayuso (1991)264287-10 [-31, 12]
Calès (1999)102910410-1 [-9, 7]
Subtotal45176444101-5 [-9, -1]
Overall effectZ = -2.26P = 0.02
All trials
Total931188928252-7 [-12, -3]
Overall effectZ = -3.44P = 0.0006